SQL Clone version 2.5.0 can run Data Masker v6 masking sets on image databases while they are being created. This can be combined with running SQL scripts on the same image.

# Script to create a new SQL Clone data image and run a Data Masker masking set on it

Connect-SqlClone -ServerUrl 'http://sql-clone.example.com:14145'
$SqlServerInstance = Get-SqlCloneSqlServerInstance -MachineName WIN201601 -InstanceName SQL2014
$ImageDestination = Get-SqlCloneImageLocation -Path '\\red-gate\data-images'
 
$MaskingSet= New-SqlCloneMask -Path \\red-gate\masking-sets\clean-pii-data.dmsmaskset

$ImageOperation = New-SqlCloneImage -Name "AdventureWorks-$(Get-Date -Format yyyyMMddHHmmss)-Cleansed" `
    -SqlServerInstance $SqlServerInstance `
    -DatabaseName 'AdventureWorks' `
    -Destination $ImageDestination `
    -Modifications $MaskingSet
 
Wait-SqlCloneOperation -Operation $ImageOperation

You can specify any number of modifications in any order:

# Script to create a new SQL Clone data image with both a Data Masker masking set and post-image T-SQL

Connect-SqlClone -ServerUrl 'http://sql-clone.example.com:14145'
$SqlServerInstance = Get-SqlCloneSqlServerInstance -MachineName WIN201601 -InstanceName SQL2014
$ImageDestination = Get-SqlCloneImageLocation -Path '\\red-gate\data-images'

$MaskingSet= New-SqlCloneMask -Path \\red-gate\masking-sets\clean-pii-data.dmsmaskset
$PermissionsScript = New-SqlCloneSqlScript -Path \\red-gate\data-scripts\change-permissions.sql

$ImageOperation = New-SqlCloneImage -Name "AdventureWorks-$(Get-Date -Format yyyyMMddHHmmss)-CleansedAndWithPermissionsChanges" `
    -SqlServerInstance $SqlServerInstance `
    -DatabaseName 'AdventureWorks' `
    -Destination $ImageDestination `
	-Modifications @($MaskingSet, $PermissionsScript)
 
Wait-SqlCloneOperation -Operation $ImageOperation